Author
BC Cancer AgencyORCID 0000-0003-4104-5486Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Farhia Kabeer, Hoa Tran, Mirela Andronescu…·Samuel A. J. R. Aparicio
The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.
Camila P. E. de Souza, Mirela Andronescu, Tehmina Masud…·Sohrab P. Shah
Epiclomal clusters sparse single-cell DNA methylation data and imputes missing values, outperforming non-probabilistic methods and revealing sub-clonal methylation patterns in tumour genomes.
The CRUK IMAXT Grand Challenge Team, Ciara H. O’Flanagan, Kieran R. Campbell…·Samuel A. J. R. Aparicio
This study identifies transcriptional stress responses in single-cell RNA-seq data from dissociated tumour tissues, showing that collagenase digestion induces a conserved stress response minimized by cold active protease.
Kieran R. Campbell, Adi Steif, Emma Laks…·Sohrab P. Shah
clonealign integrates single-cell RNA and DNA sequencing data from cancer samples to identify clone-specific gene expression patterns and dysregulated pathways.