Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons
Abeer Dagra, Douglas R. Miller, Fatemeh Shaerzadeh, Min Lin, Adithya Gopinath, Sharonda Harris, Zachary A. Sorrentino, Sophia Velasco, Adetola R. Alonge, Janelle Azar, Joe J Lebowitz, Brittany S. Ulm, Anthea-Mengfei Bu, Carissa A. Hansen, Nikhil M. Urs, , Habibeh Khoshbouei
The paper investigates how α-synuclein dysregulation affects D2 receptor activity in dopamine neurons, showing it contributes to neuronal vulnerability and identifies potential therapeutic targets.
bioRxiv · Mar 30, 2021 · PreprintNeuroscience