Author

Adithya Gopinath

University of FloridaORCID 0000-0002-6674-2301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Habibeh KhoshboueiiD· 5 shared Abeer DagraiD· 2 shared Adolfo Ramirez‐ZamoraiD· 2 shared Benoit I. GiassoniD· 2 shared Carissa A. HanseniD· 2 shared Douglas R. MilleriD· 2 shared Leah T. PhaniD· 2 shared Michael S. OkuniD· 2 shared

Activity by Year

2021-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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5 shared papersNeuroscience

Habibeh KhoshboueiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA

Leah T. Phan, D Miller, Adithya Gopinath, Min Lin, D Gunther, K Kiel, S Quintin, D Borg, Zahra Hasanpour Segherlou, A Newman, Zachary A. Sorrentino, J Miller E, Jordan M. Seibold, B Hoh, Benoit I. Giasson, Habibeh Khoshbouei

This study shows that alpha-synuclein elevates firing rates and impairs homeostatic regulation in SNc dopamine neurons, but not VTA neurons, before neurodegeneration occurs.

npj Parkinson s Disease · Jul 11, 2025Peer-reviewedNeuroscience

Midbrain dopamine neuronal activity modulates splenic immunity through a brain-to-body circuit

Adithya Gopinath, Alfonso junior Apicella, Alice Bertero, Leah T. Phan, Emily Miller, Jordan Seibold, Shannon C. Wall, Jordan Follett, Aidan R. Smith, Elijah Freedman, Lauryn Hornstein, Logan Wood, Hannah Ciupe, Diya Behal, Arianna Grillo, , Habibeh Khoshbouei

This study shows midbrain dopamine neurons modulate splenic immunity via a brain-to-body circuit involving the DVC and celiac ganglion, reducing spleen weight and naive CD4+ T-cell populations.

bioRxiv · Dec 5, 2024 · PreprintNeuroscience

Functional characterization of the biogenic amine transporter system on human macrophages

Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa M. Nielsen, Rachel Ann Nolan, Kaitlyn Runner, Stephanie M. Matt, John McNamee, Joshua E. Riklan, Kengo Adachi, Andria L. Doty, Adolfo Ramirez‐Zamora, Long Yan, Peter J. Gaskill, Wolfgang J. Streit, , Habibeh Khoshbouei

This study identifies a DAT-mediated immuno-modulatory mechanism in human macrophages, showing dopamine transport regulates innate immune responses to LPS and is disrupted in disease.

bioRxiv · Sep 8, 2021 · PreprintNeuroscience

TNFα increases Tyrosine Hydroxylase expression in human monocytes

Adithya Gopinath, Martin Badov, Madison L. Francis, Gerry Shaw, Anthony Collins, Douglas R. Miller, Carissa A. Hansen, Phillip M. Mackie, Malú G. Tansey, Abeer Dagra, Irina Madorsky, Adolfo Ramirez‐Zamora, Michael S. Okun, Wolfgang J. Streit, Habibeh Khoshbouei

The paper develops a sensitive Bio-ELISA to measure TH in immune cells and finds that TNFα increases TH expression in monocytes from Parkinson's patients.

npj Parkinson s Disease · Jul 20, 2021Peer-reviewedNeuroscience

Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons

Abeer Dagra, Douglas R. Miller, Fatemeh Shaerzadeh, Min Lin, Adithya Gopinath, Sharonda Harris, Zachary A. Sorrentino, Sophia Velasco, Adetola R. Alonge, Janelle Azar, Joe J Lebowitz, Brittany S. Ulm, Anthea-Mengfei Bu, Carissa A. Hansen, Nikhil M. Urs, , Habibeh Khoshbouei

The paper investigates how α-synuclein dysregulation affects D2 receptor activity in dopamine neurons, showing it contributes to neuronal vulnerability and identifies potential therapeutic targets.

bioRxiv · Mar 30, 2021 · PreprintNeuroscience