Surface charge tuning of lipid-polymer hybrid nanoparticles for optimized cilostazol delivery and platelet compatibility
María Francisca Matus, Bruno A. Cisterna, Marcelo Mario Mariscal, Claudia Carranza, Martín Ludueña, S. Alexis Paz, Javier Salazar-Muñoz, A. Said Álamos-Musre, Eduardo Fuentes Q, Joel B. Alderete, Esteban F. Durán‐Lara, Ricardo Ignacio Castro, Iván Palomo, Cristián Vilos
This study designs lipid-polymer hybrid nanoparticles with different surface charges to optimize cilostazol delivery and platelet compatibility, finding that negatively charged nanoparticles are most effective and safe.
bioRxiv · Sep 29, 2026 · PreprintPharmacology & Toxicology