Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats
Stephanie M. Muscat, Nicholas P. Deems, Bryan D. Alvarez, Michael J Butler, Brigitte M. González Olmo, Dominic Kolonay, Hannah F Sanders, Emmanuel A. Scaria, Sabrina E. Mackey-Alfonso, Jade A. Blackwell, James W. DeMarsh, Menaz N. Bettes, Tam Quach, Giuseppe P. Cortese, Erica R. Glasper, , Ruth M. Barrientos
This study identifies hippocampal mitochondrial dysfunction as a key mechanism underlying opioid-induced postoperative cognitive dysfunction in aged rats and shows that mitochondrial rejuvenation can reverse memory deficits.
Brain Behavior and Immunity · Aug 3, 2026Peer-reviewedAnimal Behavior & Cognition