Mucosal vaccine-elicited IgA is protective against zoonotic Betacoronavirus challenge
Junghwa Seo, Emma Buck, Bryan Machani, Oscar Javier Murillo, Breetika Maharjan, Renata B. Filler, Kevin O. Saunders, Craig B. Wilen, Benjamin Israelow, David R. Martinez
This study shows that intranasal vaccination with a synthetic spike protein and adjuvants elicits durable mucosal IgA and protects against zoonotic SARS-like coronaviruses.
bioRxiv · Aug 28, 2026 · PreprintImmunology