pr-independent biogenesis of infectious mature Zika virus particles
Kimberly A. Dowd, Michelle Schroeder, Egan Sanchez, Beniah Brumbaugh, Bryant M. Foreman, Katherine E. Burgomaster, Wei Shi, Lingshu Wang, Natalie Caputo, David N. Gordon, Cindi L. Schwartz, Bryan T. Hansen, Adam S. Olia, Mehin Suleiman, Jessica L. Guyette, , Theodore C. Pierson
This study shows that Zika virus particles can form without the prM protein and proteolytic activation, and M-E vaccines induce neutralizing antibodies regardless of maturation state.
Science Translational Medicine · Aug 12, 2026Peer-reviewedMicrobiology