Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells.
Justin Kim, Bryce Brunetti, Ayanesh Kumar, Ankit Mangla, Kord S. Honda, Akihiro Yoshida
This paper shows that inhibiting glutaminase 1 (GLS1) kills senescent melanoma cells induced by CDK4/6 inhibitors, even when those cells are resistant to BRAF inhibitors.
Cell Death and Disease · Dec 18, 2024Peer-reviewedCancer Biology