CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression
Daniela Samaniego‐Castruita, Isabella Han, Roxroy C. Morgan, Samantha Carpenter, Bryce Williams, Abhijit Chakraborty, Ishwar Radhakrishnan, Ferhat Ay, Samuel A. Myers, Anjana Rao, Vipul Shukla
This study identifies CTCF as a strong G4 DNA binder and shows its role in genome topology and gene expression through chromatin looping and CTCF occupancy.
Proceedings of the National Academy of Sciences · May 27, 2026Peer-reviewedMolecular Biology