Samuel A. Myers

PrEditR is a tool for designing sgRNAs for CRISPR-based base editors, allowing users to target specific amino acids and annotate resulting mutations.

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

The paper demonstrates that background proteome correction improves the accuracy of identifying dynamic protein-protein interactions by reducing false positives and negatives in AP-MS experiments.

This study identifies CTCF as a strong G4 DNA binder and shows its role in genome topology and gene expression through chromatin looping and CTCF occupancy.

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

This study identifies aspartic proteases as active enzymes in acidified wound fluid, showing their activity is optimal between pH 3.0 and 3.8 and persists for ten days post-injury.

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

This study examines how different heterozygous TRIO variants in mice affect behavior, brain development, and synaptic function, revealing distinct phenotypes linked to neurodevelopmental disorders.

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

The paper identifies a regulatory helix in TRAK that mediates switching between kinesin- and dynein-driven mitochondrial transport in response to stress.

This study shows that neuronal activity increases mitochondrial O-GlcNAcylation, which helps neurons meet energy demands based on fuel availability.

The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.

The paper introduces APEX-PS to map RNA binding proteins in cellular compartments, identifying SYNJ2BP as a mitochondrial mRNA anchor that aids stress recovery.

This study maps RNA-protein interactions in living cells using MS2 and Cas13-based APEX2 targeting, identifying novel interactions like hTR and ALKBH5.

Specter improves DIA proteomics by directly deconvoluting spectra using linear algebra, enhancing sensitivity for similar peptides and challenging cases.