Hyperglycemia transcriptionally regulates the paranodal protein (Caspr1) in retinal neurons and modulates neurite extension
S Sharma, S Shree, G Suresh, H Chakravarthy, M Schmelz, KK Bali, Sushma Dagar, BS Sahu, I Kaur, Vasudharani Devanathan
This study shows hyperglycemia reduces Caspr1 expression in retinal neurons via Akt and C/EBP pathways, promoting neurite outgrowth, while insulin treatment under hyperglycemia decreases Caspr1 and shortens neurites.
bioRxiv · Jan 3, 2026 · PreprintCell Biology