Hyperglycemia transcriptionally regulates the paranodal protein (Caspr1) in retinal neurons and modulates neurite extension
S Sharma, S Shree, G Suresh…·Vasudharani Devanathan
This study shows hyperglycemia reduces Caspr1 expression in retinal neurons via Akt and C/EBP pathways, promoting neurite outgrowth, while insulin treatment under hyperglycemia decreases Caspr1 and shortens neurites.