Polo-like kinase 1 controls activation of adult neural stem cells and represents a druggable entry-point to boost adult neurogenesis
Ana L. Barrios-Muñoz, Coral López-Fonseca, Elena Gutiérrez-Galindo, José Manuel Morante‐Redolat, Antonio Jordán‐Pla, Btissam Ben-Said, Maria Arroyo-Camunas, Alonso M. Higuero, Francisco Zafra, Teresa Iglesias, Isabel Fariñas, Marcos Malumbres, Eva Porlan
This study identifies Polo-like kinase 1 (Plk1) as a regulator of adult neural stem cell quiescence and activation, showing that its inhibition enhances neurogenesis.
bioRxiv · May 14, 2026 · PreprintNeuroscience