A Novel VWF Knockout Endothelial Cell Model to Study Von Willebrand Factor Biology and Von Willebrand Disease Mechanisms
Isabel Bär, Petra E. Bürgisser, Buram Ardic, Jeroen C.J. Eikenboom, Jan Voorberg, Frank W.G. Leebeek, Ruben Bierings
The paper introduces a VWF-knockout endothelial cell model to study VWF variants and their impact on von Willebrand disease, showing it can distinguish pathogenic from non-pathogenic variants.
bioRxiv · Apr 3, 2026 · PreprintCell Biology