Selective inhibition of histone deacetylase 1 and 3 improves motor phenotype and alleviates transcriptional dysregulation in Huntington's disease mice
Katharina Hecklau, Susanne G. Mueller, Stefan Koch, Mustafa Hussain Mehkary, Busra Kilic, Christoph Harms, Philipp Boehm‐Sturm, Ferah Yildirim
This study shows that inhibiting HDAC1 and HDAC3 with RGFP109 improves motor function and corrects gene expression in a Huntington's disease mouse model.
bioRxiv · Oct 13, 2020 · PreprintNeuroscience