The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation
M.-R. Abrahams, S. B. Joseph, N. Garrett, L. Tyers, M. Moeser, N. Archin, O. D. Council, D. Matten, S. Zhou, D. Doolabh, C. Anthony, N. Goonetilleke, S. A. Karim, D. M. Margolis, S. Kosakovsky Pond, , R. Swanstrom
The paper shows that most of the long-lived HIV-1 latent reservoir forms near the time of antiretroviral therapy initiation, not continuously during untreated infection.
bioRxiv · Jan 4, 2019Microbiology