Author

N. Goonetilleke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. M. Margolis· 2 shared N. Archin· 2 shared A. Bosque· 1 shared A. Chitrakar· 1 shared A. D. Cooper-Volkheimer· 1 shared A. M. K. Weideman· 1 shared A. R. Coffey· 1 shared A. R. Ward· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

D. M. Margolis

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3 papers

Recent·Most cited

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.

L. Semenova, Y. Wang, S. D. Falcinelli, N. Archin, A. D. Cooper-Volkheimer, N. Goonetilleke, D. M. Murdoch, C. D. Rudin, D. M. Margolis, E. P. Browne

The paper uses machine learning to analyze HIV reservoir and immunology data to identify immune signatures associated with total and intact HIV DNA levels during ART.

bioRxiv · Nov 16, 2023Microbiology

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1

M. Sanz, A. M. K. Weideman, A. R. Ward, M. L. Clohosey, S. Garcia-Recio, S. R. Selitsky, B. T. Mann, M. A. Iannone, C. P. Whitworth, A. Chitrakar, C. Garrido, J. Kirchherr, A. R. Coffey, Y.- H. Tsai, S. Samir, , N. Soriano-Sarabia

This study shows that aminobisphosphonates reactivate latent HIV-1 in ART-suppressed individuals and activate immune effector cells, but do not significantly reduce the viral reservoir.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation

M.-R. Abrahams, S. B. Joseph, N. Garrett, L. Tyers, M. Moeser, N. Archin, O. D. Council, D. Matten, S. Zhou, D. Doolabh, C. Anthony, N. Goonetilleke, S. A. Karim, D. M. Margolis, S. Kosakovsky Pond, , R. Swanstrom

The paper shows that most of the long-lived HIV-1 latent reservoir forms near the time of antiretroviral therapy initiation, not continuously during untreated infection.

bioRxiv · Jan 4, 2019Microbiology