R. Swanstrom

Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection

The paper measures CSF proteins in HIV-1 infected and uninfected individuals, identifying patterns of protein changes associated with CNS injury and treatment effects.

N4-Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness

This study shows that N4-hydroxycytidine and its prodrug molnupiravir reduce RNA-virus-induced encephalitis by producing less fit viruses with G-to-A and C-to-U mutations.

Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

This study identifies two independent resistance pathways to fifth-generation protease inhibitors in HIV-1 by analyzing mutations under high drug concentrations.

Deep Sequencing Reveals Compartmentalized HIV-1 in the Semen of Men with and without STI-associated Urethritis

This study examines HIV-1 compartmentalization in semen of men with and without STI-associated urethritis, finding stable viral populations and limited replication despite STI treatment.

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

Acetylation of cytidine residues boosts HIV-1 gene expression by increasing viral RNA stability

This study shows HIV-1 transcripts are acetylated at cytidine residues by NAT10, enhancing viral RNA stability and gene expression, suggesting ac4C as a potential antiviral target.

Constrained mutational sampling of amino acids in HIV-1 protease evolution

The paper investigates HIV-1 protease evolution by comparing experimental fitness landscapes with sequenced isolate data, showing mutational sampling influences multiple mutations.

The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation

The paper shows that most of the long-lived HIV-1 latent reservoir forms near the time of antiretroviral therapy initiation, not continuously during untreated infection.

HIV-1 Protease Uses Bi-Specific S2/S2’ Subsites To Optimize Cleavage of Two Classes of Target Sites

This study shows HIV-1 protease uses bi-specific S2/S2’ subsites to cleave two classes of target sites, with distinct interactions based on the presence or absence of a P1 proline.