SETDB1 modulates the TGFbeta response in Duchenne muscular dystrophy myotubes
A. GRANADOS, M. ZAMPERONI, R. RAPONE, M. MOULIN, E. BOYARCHUK, C. BOUYIOUKOS, L. DEL MAESTRO, V. JOLIOT, E. NEGRONI, M. MOHAMED, S. PIQUET, A. BIGOT, F. LE GRAND, S. ALBINI, S. AIT-SI-ALI
This study shows that SETDB1 enhances TGFβ-driven fibrosis in DMD myotubes by modulating TGFβ-target gene expression and secretome effects on myoblast differentiation.
bioRxiv · Jun 28, 2023Cell Biology