F. Le Grand

SETDB1 modulates the TGFbeta response in Duchenne muscular dystrophy myotubes

This study shows that SETDB1 enhances TGFβ-driven fibrosis in DMD myotubes by modulating TGFβ-target gene expression and secretome effects on myoblast differentiation.

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

This study shows that Setdb1 in muscle stem cells prevents endogenous retrovirus activation and maintains genome stability, which is essential for muscle regeneration and inflammation control.

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

This study shows that muscle stem cells in their native niche experience mechanical deformation from myofiber stretch-shortening and respond with increased nitric oxide production and gene expression related to proliferation.

Bioengineering a Miniaturized In Vitro 3D Myotube Contraction Monitoring Chip For Modelization of Muscular Dystrophies

This paper develops a miniaturized 3D myotube contraction monitoring chip to model muscular dystrophies, showing contractile dysfunction in L-CMD mutant myotubes with reduced starting material requirements.

GLI3 Processing by the Primary Cilium Regulates Muscle Stem Cell Entry into GAlert

This study shows that GLI3 processing by primary cilia maintains satellite cell dormancy and that its absence leads to premature activation and enhanced regenerative capacity.

Trophic niche of the invasive gregarious species Crepidula fornicata, in relation to ontogenic changes

The paper investigates trophic niche changes in Crepidula fornicata across ontogenic stages using fatty acids and stable isotopes, finding no significant trophic niche shift despite behavioral and physiological changes.

Differential myoblast and tenoblast affinity to collagen, fibrin and mixed threads in the prospect of muscle-tendon junction modelisation

The paper investigates the differential affinity of myoblasts and tenoblasts to collagen, fibrin, and mixed threads to model muscle-tendon junction behavior.

GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

This study identifies an epigenetic reprogramming of GREM1 in muscle cells after exercise training, which enhances myogenesis and metabolism through the AMPK pathway.

TGFβ signaling curbs cell fusion and muscle regeneration

This study shows that TGFβ signaling inhibits muscle cell fusion and regeneration, with inhibition promoting fusion and muscle repair.

High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations

This study maps adult skeletal muscle cell types using single-cell RNA-sequencing and mass cytometry, identifying two novel populations with myogenic potential.