Author

C. C. Yap

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

B. Winckler· 5 shared L. Digilio· 3 shared C. J. Bott· 2 shared C. G. Johnson· 1 shared D. A. Garcia· 1 shared J. Keil· 1 shared K. Kwan· 1 shared K. Newell-Litwa· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCell Biology

B. Winckler

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5 papers

Recent·Most cited

Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP.

R. J. Mulligan, M. M. Magaj, L. Digilio, S. Redemann, C. C. Yap, B. Winckler

The paper shows that neutralizing late endosomal pH via LLOMe or NH4Cl hyper-activates Rab7 through V-ATPase and RILP, disrupting tubulation and CI-M6PR trafficking.

bioRxiv · Oct 24, 2023Cell Biology

Validation of species-specificity of two commercial antibodies directed against RILP (Rab-interacting lyosomal protein).

C. C. Yap, L. Digilio, B. Winckler

The paper validates two commercial anti-RILP antibodies, finding they only recognize human RILP and show differential behavior in neurons versus HEK293 cells.

bioRxiv · Nov 1, 2022 · PreprintCell Biology

Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons

C. J. Bott, L. P. McMahon, J. Keil, C. C. Yap, K. Kwan, B. Winckler

bioRxiv · Mar 10, 2020Cell Biology

Nestin in immature embryonic neurons regulates axon growth cone morphology and Sema3a sensitivity

C. J. Bott, C. G. Johnson, C. C. Yap, N. D. Dwyer, K. Newell-Litwa, B. Winckler

This study shows that nestin in immature neurons modulates cdk5 activity, affecting sensitivity to the guidance cue Sema3a, which influences axon growth cone morphology.

bioRxiv · Jan 14, 2019 · PreprintCell Biology

Bulk degradation of dendritic cargos requires Rab7-dependent transport in Rab7-positive/LAMP1-negative endosomes to somatic lysosomes.

C. C. Yap, L. Digilio, L. McMahon, D. A. Garcia, B. Winckler

bioRxiv · Nov 8, 2017Cell Biology