C. Cabo

Multichannel Modulation of Depolarizing and Repolarizing Ion Currents Increases the Positive Rate Dependence of Action Potential Prolongation

This paper shows that modulating both depolarizing and repolarizing ion currents in cardiac cells leads to positive rate-dependent action potential prolongation, which is anti-arrhythmic and reduces pro-arrhythmic risks.

POSITIVE RATE DEPENDENT ACTION POTENTIAL PROLONGATION BY MODULATING POTASSIUM ION CHANNELS

The paper shows that combining IKs activators with IKr and IK1 blockers can produce APD prolongation with strong positive rate dependence and reduced pro-arrhythmic risk.