Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling
J. Nguyen, L. Wang, W. Lei, Y. Hu, N. Gulati, C. Chavez-Madero, H. Ahn, H. J. Ginsberg, R. Krawetz, M. Brandt, T. Betz, P. M. Gilbert
This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.
bioRxiv · Aug 8, 2023Bioengineering