J. Nguyen

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition.

The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.

In Situ-Crosslinked Zippersomes Enhance Cardiac Repair by Increasing Accumulation and Retention

This paper develops HiA Zippersomes to enhance EV accumulation and retention in the infarcted myocardium, improving cardiac function and reducing infarct size.

A reference database of reptile images

The paper presents a standardized reference database of 14,000 reptile images from 20 collections, aiming to improve accessibility, interoperability, and comparability of reptile image data.

AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans

This study identifies AXDND1's role in balancing spermatogonial commitment and sperm tail formation in mice and humans, showing its necessity for fertility.

Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling

This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.

The great divide: rhamnolipids mediate separation between P. aeruginosa and S. aureus

This study shows that rhamnolipids mediate physical separation between P. aeruginosa and S. aureus, enabling coexistence through surfactant flow deflection.

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

This study shows that tumor organoids with mutant p53 are more sensitive to the combination of PARP inhibitor and temozolomide than those with wild-type p53.

Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

The paper uses NMR, molecular dynamics, and pharmacology to study conformational changes in the V2R receptor bound to different ligands, revealing a mechanism for Gs-biased agonism involving TM7 and TM3 interactions.

Characterizing the microbiome of patients with myeloproliferative neoplasms during a Mediterranean diet intervention

This study investigates the impact of a Mediterranean diet on the gut microbiome and inflammation in MPN patients, finding stable microbiome composition but associations between bacterial taxa and cytokine levels.

QC-GN2oMS2: a Graph Neural Net for High Resolution Mass Spectra Prediction.

The paper develops a graph neural network (GNN) that incorporates quantum chemical features to improve mass spectrum prediction, achieving better performance than baseline models.

Dystrophin is a mechanical tension modulator

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair

This paper develops a bioadhesive patch with instant adhesion, ultra-elasticity, and therapeutic delivery capabilities for organ and wound repair.

Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1

This study identifies KATNA1 and KATNAL1 as critical for male meiosis and spermiogenesis, showing their roles in spindle formation, cytokinesis, and sperm structure.

CosTaL: An Accurate and Scalable Graph-Based Clustering Algorithm for High-Dimensional Single-Cell Data Analysis

CosTaL is a graph-based clustering algorithm for single-cell data that improves clustering effectiveness and scalability compared to existing methods.

Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.

This study predicts microbiota responses to environmental pH and osmolality by analyzing bacterial growth under controlled conditions and identifying predictive genes and pathways.

Breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome

This study examines breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome, finding age-related differences in respiratory responses and lung tissue damage that may contribute to SUDEP.

Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

The paper identifies a genetic mechanism in Fulani individuals that enhances splenic clearance of rigid erythrocytes, contributing to splenomegaly and partial malaria resistance.

Synthetic Multiantigen MVA Vaccine COH04S1 Protects Against SARS-CoV-2 in Syrian Hamsters and Non-Human Primates

This paper shows that the synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates through various vaccination routes and dose regimens.

Longitudinal immune cell profiling in early systemic lupus erythematosus

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

Fluorogenic EXO-Probe Aptamers for Imaging and Tracking Exosomal RNAs

This paper develops a fluorogenic EXO-Probe Aptamer system to visualize and track exosomal RNAs, enabling imaging, quantification, and colocalization with cellular markers.

Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota

This study finds altered IgA responses to gut and oral microbiota in axial spondyloarthritis patients using IgA-SEQ and metagenomic analysis.

Differential impact of TNFRSF co-stimulation on CD8+ T cell cytokine production by feedback control of surface receptor expression

This study investigates how different TNFRSF co-stimulation receptors affect CD8+ T cell cytokine production, revealing that feedback control of surface receptor expression explains their differential impact.

Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts

The paper develops and validates an open-source 3D-printed in vitro system to study cannabis smoke exposure on human airway epithelial cells, showing changes in morphology and cytokine expression without significant cytotoxicity.

A distinct growth physiology enhances bacterial growth under rapid nutrient fluctuations

This study shows that E. coli grown in fluctuating nutrient environments has a distinct physiology that reduces growth rate loss compared to steady environments with the same average nutrient concentration.

CryoFold: Ab-initio structure determination from electron density maps using molecular dynamics

CryoFold determines protein structures from electron density maps using molecular dynamics and physical knowledge, producing ensembles of low-energy conformations validated experimentally.

Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

Human CD8+ T cells exhibit a shared antigen threshold for different effector responses

The paper shows that different effector responses of human CD8+ T cells share a common antigen threshold across varying affinities and co-stimulatory conditions.

Boosting the biogenesis and secretion of mesenchymal stem cell-derived exosomes

This study identifies small molecule modulators that enhance exosome secretion from mesenchymal stem cells without affecting their functional properties.