DNA Binding Induces a cis to trans Switch in Cre Recombinase to Enable Intasome Assembly
A. Unnikrishnan, C. D. Amero, D. K. Yadav, K. Stachowski, D. Potter, M. Foster
This paper uses NMR to show that Cre recombinase undergoes a cis-to-trans conformational switch upon DNA binding, enabling intasome assembly and DNA recombination.
bioRxiv · May 24, 2020Biophysics