Author

C. D. Christ

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:benchmark study· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Volkamer· 1 shared D. Schaller· 1 shared F. Noe· 1 shared J. D. Chodera· 1 shared J. Günther· 1 shared K. Meier· 1 shared L. Raich· 1 shared S. Olsson· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

A. Volkamer

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2 papers

Recent·Most cited

Benchmarking Cross-Docking Strategies for Structure-Informed Machine Learning in Kinase Drug Discovery

D. Schaller, C. D. Christ, J. D. Chodera, A. Volkamer

This study benchmarks docking strategies for generating kinase:inhibitor complex geometries to improve machine learning scoring in drug discovery, finding that combining shape and electrostatics-based methods achieves the highest success rate.

bioRxiv · Sep 11, 2023 · PreprintBiophysics

Discovery of a hidden transient state in all bromodomain families

L. Raich, K. Meier, J. Günther, C. D. Christ, F. Noe, S. Olsson

The paper identifies a transient state in all bromodomain families using molecular dynamics simulations and structural data, suggesting it acts as an allosteric regulatory switch.

bioRxiv · Apr 1, 2020Biophysics