Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2
A. Sethi, S. Bruell, T. Ryan, F. Yan, M. H. Tanipour, Y. F. Mok, C. D. Joyce, Y. Khandokar, R. D. Metcalfe, M. D. W. Griffin, D. J. Scott, M. A. Hossain, E. J. Petrie, R. A. D. Bathgate, P. R. Gooley
The paper identifies a conserved motif critical for RXFP1 and RXFP2 activation, showing distinct structural roles in receptor activity.
bioRxiv · Jun 6, 2021Biophysics