M. A. Hossain

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

SGC-CAMKK2-1: A chemical probe for CAMKK2

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4

This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

Genomic diversity and molecular epidemiology of a multidrug resistant Pseudomonas aeruginosa DMC30b isolated from hospitalized burn patient in Bangladesh

This paper reports the complete genome sequence of a multidrug-resistant Pseudomonas aeruginosa strain isolated from a burn patient in Bangladesh, revealing its genetic diversity, molecular epidemiology, and resistance mechanisms.

Metagenomic analysis reveals the abundance and diversity of opportunistic fungal pathogens in the nasopharyngeal tract of COVID-19 patients

This study uses metagenomic analysis to show that SARS-CoV-2 infection increases opportunistic fungal pathogens in the nasopharyngeal tract while reducing commensal fungi.

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

Exploring of bacterial blight resistance in landraces, mining of resistant gene(s) and genetic divergence of resistant germplasm through molecular markers and quantitative traits.

The paper evaluates bacterial blight resistance in rice landraces, identifies resistant genes, and assesses genetic diversity using molecular markers and quantitative traits.

Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2

The paper identifies a conserved motif critical for RXFP1 and RXFP2 activation, showing distinct structural roles in receptor activity.

Microbiome dysbiosis regulates the level of energy production under anaerobic condition

This study examines microbiome dysbiosis in anaerobic digesters, finding that specific bacterial and archaeal strains correlate with higher energy production.

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Genome-wide Genetic Marker Analysis and Genotyping of Escherichia fergusonii strain OTSVEF-60

This study reports the complete genome analysis of Escherichia fergusonii strain OTSVEF-60, identifying antibiotic resistance genes, virulence genes, and mobile genetic elements associated with its pathogenicity and antimicrobial resistance.

DNA barcodes and reliable molecular identifications in a diverse group of invasive pests: lessons from Bactrocera fruit flies on variation across the COI gene, introgression, and standardization

The paper evaluates the effectiveness of COI gene sequences for species identification in Dacini fruit flies, finding high congruence with morphology but also introgression issues in some pest species.

Microbiome Dynamics of Bovine Mastitis Progression and Genomic Determinants

This study profiles microbiome dynamics across mastitis states in cows, identifying virulence factors, antibiotic resistance genes, and functional correlations to inform diagnostics and therapeutics.

Evolutionary dynamics of SARS-CoV-2 nucleocapsid protein (N protein) and its consequences

This study analyzes mutations in the SARS-CoV-2 N protein across 61,485 sequences, identifying 1034 nucleotide mutations and 684 amino acid substitutions, and their potential impact on diagnostic primers and protein structure.

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach

This study designs a chimeric peptide vaccine against SARS-CoV-2 S, M, and E proteins using in silico methods, showing high population coverage and predicted immune responses.

Multidrug-Resistant Avian Pathogenic Escherichia coli Strains and Association of Their Virulence Genes in Bangladesh

This study identifies prevalent APEC phylotypes and their virulence and resistance genes in Bangladesh poultry farms, highlighting associations between specific phylotypes and pathogenicity.

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline

The paper develops a fast and accurate pipeline to identify nonsynonymous mutations and deletions in SARS-CoV-2 spike protein sequences from large datasets.

Resistome diversity in bovine clinical mastitis microbiome, a signature concurrence

This study identifies resistome diversity in bovine clinical mastitis microbiomes and links it to microbiome composition and antibiotic resistance.

Megacities as drivers of national outbreaks: the role of holiday travel in the spread of infectious diseases

The paper uses mobile phone data and household surveys to show that holiday travel in Dhaka amplified chikungunya spread nationally during 2017.

Emergence of Novel Lineage of Foot-and-Mouth Disease Virus Serotype Asia1 BD-18 (G-IX) in Bangladesh

The paper reports the emergence of a novel Foot-and-Mouth Disease Virus serotype Asia1 BD-18 (G-IX) lineage in Bangladesh with a unique mutation, linked to vaccination practices and surveillance inefficiencies.