Author

R. D. Metcalfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

M. D. W. Griffin· 2 shared P. R. Gooley· 2 shared A. P. Leis· 1 shared A. Sethi· 1 shared C. C. Kosasih· 1 shared C. D. Joyce· 1 shared C. J. Morton· 1 shared C. O. Zlatic· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

M. D. W. Griffin

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

R. D. Metcalfe, E. Hanssen, K. Y. Fung, K. Aizel, C. C. Kosasih, C. O. Zlatic, L. Doughty, C. J. Morton, A. P. Leis, M. W. Parker, P. R. Gooley, T. L. Putoczki, M. D. W. Griffin

This study presents cryo-EM and crystal structures of the IL-11 signalling complex, revealing dynamics of gp130 and the inhibitory mechanism of a cytokine variant.

bioRxiv · Jul 21, 2022Cell Biology

Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2

A. Sethi, S. Bruell, T. Ryan, F. Yan, M. H. Tanipour, Y. F. Mok, C. D. Joyce, Y. Khandokar, R. D. Metcalfe, M. D. W. Griffin, D. J. Scott, M. A. Hossain, E. J. Petrie, R. A. D. Bathgate, P. R. Gooley

The paper identifies a conserved motif critical for RXFP1 and RXFP2 activation, showing distinct structural roles in receptor activity.

bioRxiv · Jun 6, 2021Biophysics