Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting beta cell differentiation
R. E. Stamateris, R. B. Sharma, H. V. Landa-Galvan, C. Darko, D. Redmond, S. G. Rane, L. C. Alonso
This study shows that CDK4-R24C rescues beta cell mass and dedifferentiation in Irs2-deficient mice by inhibiting FOXO1-mediated repression of Pdx1, independent of insulin sensitivity.
bioRxiv · Oct 19, 2022 · PreprintCell Biology