E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1
C. Drews, S. Case, S. Vande Pol
This paper identifies NHERF1 as a conserved target of degradation by both high- and low-risk HPV E6 proteins and animal papillomavirus E6 proteins, leading to activation of the Wnt/β-catenin pathway.
bioRxiv · Jan 11, 2019Microbiology