Hepatocyte cholesterol content modulates glucagon receptor signalling
E. R. McGlone, T. B. Ansell, C. Dunsterville, W. Song, D. Carling, A. Tomas, S. R. Bloom, M. Sansom, T. M. Tan, B. Jones
This study shows that hepatocyte cholesterol content affects glucagon receptor signaling, with higher cholesterol reducing glucagon's ability to lower blood sugar in NAFLD.
bioRxiv · Oct 31, 2021Pharmacology & Toxicology