Author

T. B. Ansell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:statistical model· 3 Approach:deep learning· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Siebold· 4 shared M. S. P. Sansom· 4 shared W. Song· 4 shared C. E. Coupland· 3 shared P. J. Stansfeld· 3 shared R. A. Corey· 3 shared L. Carrique· 2 shared M. Sansom· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiophysics

C. Siebold

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mapping Structural and Dynamic Divergence Across the MBOAT family

T. B. Ansell, M. Healy, C. E. Coupland, M. S. P. Sansom, C. Siebold

This study uses molecular dynamics and bioinformatics to analyze structural and dynamic differences across MBOAT family members, identifying key features relevant to inhibitor design.

bioRxiv · Dec 18, 2023Biochemistry

LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

T. B. Ansell, W. Song, C. E. Coupland, L. Carrique, R. A. Corey, A. L. Duncan, C. K. Cassidy, M. M. G. Guerts, T. Rasmussen, A. B. Ward, C. Siebold, P. J. Stansfeld, M. Sansom

LipIDens uses MD simulations to interpret lipid-like densities in cryo-EM maps of membrane proteins, revealing protein-lipid interactions.

bioRxiv · Jun 30, 2022Biophysics

Hepatocyte cholesterol content modulates glucagon receptor signalling

E. R. McGlone, T. B. Ansell, C. Dunsterville, W. Song, D. Carling, A. Tomas, S. R. Bloom, M. Sansom, T. M. Tan, B. Jones

This study shows that hepatocyte cholesterol content affects glucagon receptor signaling, with higher cholesterol reducing glucagon's ability to lower blood sugar in NAFLD.

bioRxiv · Oct 31, 2021Pharmacology & Toxicology

Structure and Mechanism of Hedgehog Acyl Transferase

C. E. Coupland, S. A. Andrei, T. B. Ansell, L. Carrique, P. Kumar, L. Sefer, R. A. Schwab, E. F. X. Byrne, E. Pardon, J. Steyaert, A. I. Magee, M. S. P. Sansom, E. W. Tate, C. Siebold

The paper presents the cryo-EM structure of HHAT, revealing its mechanism for transferring palmitate to SHH and identifying a heme group essential for its function.

bioRxiv · Jul 8, 2021 · PreprintBiophysics

Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

T. B. Ansell, L. Curran, M. R. Horrell, T. Pipatpolkai, S. C. Letham, W. Song, C. Siebold, P. J. Stansfeld, M. S. P. Sansom, R. A. Corey

This study develops a method to determine protein-lipid binding affinities from MD simulations and validates it against experimental and computational methods.

bioRxiv · Jun 2, 2021Biophysics

Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins

R. A. Corey, W. Song, A. Duncan, T. B. Ansell, M. S. P. Sansom, P. J. Stansfeld

The paper uses molecular dynamics simulations to analyze cardiolipin interactions with 42 E. coli inner membrane proteins, identifying over 700 binding sites and defining metrics for high-affinity cardiolipin binding.

bioRxiv · Mar 19, 2021Biochemistry