W. Song

Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

Pro-renin Receptor Inhibited ABCA1/G1 Expression Associated with Low HDL-c and Promoted Atherosclerosis

This study shows that prorenin binding to (P)RR inhibits ABCA1/ABCG1 expression and cholesterol efflux, leading to dyslipidemia and atherosclerosis in hypertension.

Regulation of fatty acid delivery to metastases by tumor endothelium

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.

Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1

This study assesses the antigenic properties and immune evasion of the SARS-CoV-2 variant BA.2.87.1, finding it less resistant to neutralizing antibodies than JN.1 but with compensatory deletions in the NTD.

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure

The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.

Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

A small number of human lineage mutations regulated RNA-protein binding of conserved genes and promoted human evolution

The paper uses deep learning to predict how human lineage mutations affect RNA-protein binding, finding that a small number of mutations in conserved brain-related genes contributed to human evolution.

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

This study shows that N-WASP-dependent branched actin polymerization drives B-cell contraction, which reduces BCR signaling by increasing receptor cluster molecular density and displacing signaling molecules.

Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

This study shows XBB.1.5 has higher ACE2 binding and moderate antibody evasion, contributing to its increased transmissibility compared to other variants.

Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

Expanding the diversity of Accumulibacter with a novel type and deciphering the transcriptional and morphological features among co-occurring strains

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

Second-generation dual-channel visible light optical coherence tomography enables wide-field, full-range, and shot-noise limited retinal imaging

This paper introduces a second-generation dual-channel VIS-OCT system that achieves wide-field, full-range, and shot-noise limited retinal imaging with improved depth resolution and SNR.

Genetic Analysis of Activin/Inhibin β Subunits in Zebrafish Development and Reproduction

This study investigates the role of activin/inhibin β subunits in zebrafish development and reproduction, showing their critical role in folliculogenesis and ovarian homeostasis.

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating Calcium-Sensing Receptor

This study shows low molecular weight hyaluronan inhibits lung epithelial ion transport by activating the calcium-sensing receptor, with effects reversed by a CaSR inhibitor or high molecular weight hyaluronan.

A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

Thriving in the heat - Lysine acetylation stabilizes the quaternary structure of a Mega-Dalton hyperthermoactive PEP-synthase

The paper investigates how lysine acetylation stabilizes the structure of a hyperthermoactive PEP-synthase from Pyrococcus furious, revealing its role in maintaining function under extreme temperatures.

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

This study shows a replicon RNA vaccine provides durable protection against SARS-CoV-2 in nonhuman primates even after neutralizing antibodies decline.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.