IL-2 secreting T helper cells promote EF B cell maturation via intrinsic regulation of B cell mTOR/AKT/Blimp-1 axis.
C. E. Faliti, M. Mesina, J. Choi, S. Belanger, W. R. Schief, S. Crotty
The paper identifies IL-2's role in promoting B cell maturation by regulating the mTOR/AKT/Blimp-1 axis through T helper cell interactions.
bioRxiv · Aug 19, 2022 · PreprintImmunology