Genetic variants disrupt human RGS14 binding to NHERF1 and regulation of NPT2A-mediated phosphate transport
P. A. Friedman, T. Mamonova, C. E. Magyar, K. E. Squires, W. B. Sneddon, D. R. Emlet, J. R. Hepler
This study identifies how genetic variants in RGS14 affect its interaction with NHERF1 and regulation of phosphate transport, showing some variants disrupt binding while others maintain function.
bioRxiv · Feb 5, 2019 · PreprintPharmacology & Toxicology