Author

J. R. Hepler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

W. B. Sneddon· 2 shared C. E. Magyar· 1 shared D. R. Emlet· 1 shared G. E. Van Doorn· 1 shared K. E. Squires· 1 shared P. A. Friedman· 1 shared P. Friedman· 1 shared S. Ramineni· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

W. B. Sneddon

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2 papers

Recent·Most cited

Structural factors of RGS14 regulating hormone-dependent phosphate transport mediated by NPT2A

W. B. Sneddon, S. Ramineni, G. E. Van Doorn, J. R. Hepler, P. Friedman

This study identifies structural elements of RGS14 that regulate hormone-sensitive phosphate transport by NPT2A, showing that phosphorylation in the linker and an intact PDZ ligand are essential.

bioRxiv · Mar 29, 2024 · PreprintCell Biology

Genetic variants disrupt human RGS14 binding to NHERF1 and regulation of NPT2A-mediated phosphate transport

P. A. Friedman, T. Mamonova, C. E. Magyar, K. E. Squires, W. B. Sneddon, D. R. Emlet, J. R. Hepler

This study identifies how genetic variants in RGS14 affect its interaction with NHERF1 and regulation of phosphate transport, showing some variants disrupt binding while others maintain function.

bioRxiv · Feb 5, 2019 · PreprintPharmacology & Toxicology