RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection.
C. E. Stamm, A. P. McFarland, M. N. Locke, H. Tabakh, Q. Tang, M. K. Thomason, J. J. Woodward
This paper uses a RECON-/- mouse model to perform Tn-seq screening of Listeria monocytogenes in vivo, identifying novel genes critical for bacterial survival and revealing the role of the D-allose operon in pathogenesis.
bioRxiv · Jan 15, 2024Microbiology