J. J. Woodward

This paper uses a RECON-/- mouse model to perform Tn-seq screening of Listeria monocytogenes in vivo, identifying novel genes critical for bacterial survival and revealing the role of the D-allose operon in pathogenesis.

This study identifies a unique GSH utilization pathway in Francisella, revealing a pseudogenized transporter gene in pathogenic strains and its role in environmental niches.

This study identifies ACBD3 and PI4P-regulating proteins as essential for STING activation and shows that modulating PI4P levels can enhance STING signaling and cytokine production.

This study shows that variability in the 3UTR of VEEV modulates IFIT2-dependent restriction, with differential sensitivity observed in vitro.

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

This paper designs a FRET biosensor, CDA5, to detect c-di-AMP dynamics in bacteria, showing unimodal distribution and response changes in mutants.

The paper shows that 4-HNE, a product of ROS during infection, is counteracted by L. monocytogenes through rha1/2 genes, enhancing bacterial survival.