Author

C. F. Abrams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Finzi· 2 shared J. Prevost· 2 shared M. Pazgier· 2 shared N. Gupta Vergara· 2 shared R. Gasser· 2 shared S. P. Anand· 2 shared A. Prive· 1 shared A. Schon· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Finzi

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Author profile →

3 papers

Recent·Most cited

Entropic overcompensation of the N501Y mutation on SARS-CoV-2 S binding to ACE2

N. Gupta Vergara, M. Gatchel, C. F. Abrams

This study uses molecular dynamics simulations to show that the N501Y mutation in SARS-CoV-2 S increases binding affinity to ACE2 by reducing entropic penalties through increased quaternary flexibility.

bioRxiv · Aug 30, 2022Biophysics

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

J. Prevost, J. Richard, R. Gasser, S. Ding, C. Fage, S. P. Anand, D. Adam, N. Gupta Vergara, A. Tauzin, M. Benlarbi, S. Y. Gong, G. Goyette, A. Prive, S. Moreira, H. Charest, , A. Finzi

This study investigates how temperature affects SARS-CoV-2 Spike protein affinity for ACE2, finding increased binding at low temperatures, which is mitigated by the N501Y mutation.

bioRxiv · Jul 9, 2021 · PreprintMicrobiology

Interaction of human ACE2 to membrane-bound SARS-CoV-1 and SARS-CoV-2 S glycoproteins

S. P. Anand, Y. Chen, J. Prevost, R. Gasser, G. Beaudoin-Bussieres, C. F. Abrams, M. Pazgier, A. Finzi

This study compares the cooperativity of ACE2 binding to SARS-CoV-1 and SARS-CoV-2 Spike proteins, finding that SARS-CoV-2 exhibits positive cooperativity.

bioRxiv · Sep 7, 2020Microbiology