Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry.
M. M. Wagner, J. Kang, C. Mercado, V. P. Thirumlaikumar, M. Gorka, H. Zillmer, J. Guo, R. I. Minen, C. F. Plecki, K. Dehesh, F. C. Schroeder, D. Walther, A. Skirycz
The paper introduces PROMIS, a co-fractionation mass spectrometry technique integrated with chromatographic methods to map protein-metabolite interactions in E. coli, identifying 994 interactions and revealing novel functional insights.
bioRxiv · Feb 14, 2024 · PreprintBiochemistry