Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation
M. T. Dickerson, P. K. Dadi, K. E. Zaborska, A. Y. Nakhe, C. M. Schaub, J. R. Dobson, N. M. Wright, J. C. Lynch, C. F. Scott, D. A. Jacobson
This study shows that Gi/o-GPCR inhibition of beta-cell insulin secretion depends on Na+/K+ ATPase activation, which hyperpolarizes the membrane and modulates Ca2+ oscillations.
bioRxiv · Feb 10, 2022Physiology