Author

P. K. Dadi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. A. Jacobson· 3 shared A. Y. Nakhe· 2 shared J. R. Dobson· 2 shared M. T. Dickerson· 2 shared C. F. Scott· 1 shared C. M. Schaub· 1 shared D. Accili· 1 shared J. C. Lynch· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

D. A. Jacobson

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3 papers

Recent·Most cited

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

A. Y. Nakhe, P. K. Dadi, J. Kim, M. T. Dickerson, S. Behera, J. R. Dobson, S. Shrestha, J.-P. Cartailler, L. Sampson, M. A. Magnuson, D. A. Jacobson

This study shows that the KCNK16 L114P mutation causes neonatal diabetes and glucose dyshomeostasis in adult mice by disrupting islet insulin secretion and increasing glucagon secretion.

bioRxiv · Jun 20, 2023 · PreprintPhysiology

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

M. T. Dickerson, P. K. Dadi, K. E. Zaborska, A. Y. Nakhe, C. M. Schaub, J. R. Dobson, N. M. Wright, J. C. Lynch, C. F. Scott, D. A. Jacobson

This study shows that Gi/o-GPCR inhibition of beta-cell insulin secretion depends on Na+/K+ ATPase activation, which hyperpolarizes the membrane and modulates Ca2+ oscillations.

bioRxiv · Feb 10, 2022Physiology

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactionsin beta-cell function

T. Kuo, W. Du, Y. Miyachi, P. K. Dadi, D. A. Jacobson, D. Accili

The paper investigates the antagonistic epistasis between Hnf4a and FoxO1 networks in beta-cell function through enhancer interactions and gene expression analysis.

bioRxiv · Jul 4, 2020 · PreprintPathology