Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses
E. Nunez-Manchon, M. Farrera-Sal, G. Castellano, D. Medel, R. Alemany, E. Villanueva, C. Fillat
This study shows that transgene codon usage affects viral fitness and oncolytic efficacy in adenoviruses, with suboptimal codons enhancing sustained expression and therapeutic activity.
bioRxiv · Jun 19, 2020Bioengineering