Author

G. Castellano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. Lopez-Guillermo· 1 shared A. Queiros· 1 shared A. Rivas· 1 shared C. Fillat· 1 shared C. Lopez-Otin· 1 shared C. Oakes· 1 shared D. Medel· 1 shared E. Campo· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Lopez-Guillermo

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2 papers

Recent·Most cited

Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses

E. Nunez-Manchon, M. Farrera-Sal, G. Castellano, D. Medel, R. Alemany, E. Villanueva, C. Fillat

This study shows that transgene codon usage affects viral fitness and oncolytic efficacy in adenoviruses, with suboptimal codons enhancing sustained expression and therapeutic activity.

bioRxiv · Jun 19, 2020Bioengineering

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

M. Duran-Ferrer, G. Clot, F. Nadeu, R. Beekman, T. Bauman, J. Nordlund, Y. Marincevic-Zuniga, G. Lonnerholm, A. Rivas, S. Martin, R. Ordonez, G. Castellano, M. Kulis, A. Queiros, L. Seung-Tae, , J. I. Martin-Subero

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

bioRxiv · Feb 6, 2020Cancer Biology