Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis
A. L. Moye, A. F. M. Dost, R. Ietswaart, S. Sengupta, V. Ya, C. Aluya, C. G. Fahey, S. M. Louie, M. Paschini, C. F. Kim
This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.
bioRxiv · Feb 27, 2024Cancer Biology