Author

A. F. M. Dost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. L. Moye· 1 shared A. Sexton-Oates· 1 shared A.-M. Dingemans· 1 shared C. Aluya· 1 shared C. F. Kim· 1 shared C. G. Fahey· 1 shared C. Voegele· 1 shared E. J. Speel· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. L. Moye

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2 papers

Recent·Most cited

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis

A. L. Moye, A. F. M. Dost, R. Ietswaart, S. Sengupta, V. Ya, C. Aluya, C. G. Fahey, S. M. Louie, M. Paschini, C. F. Kim

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.

bioRxiv · Feb 27, 2024Cancer Biology

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

T. L. Dayton, N. Alcala, L. Moonen, L. den Hartigh, L. Mangiante, L. Lap, A. F. M. Dost, J. Beumer, S. Levy, R. S. van Leeuwaarde, W. M. Hackeng, K. Samsom, C. Voegele, A. Sexton-Oates, H. Begthel, , H. Clevers

This study establishes patient-derived tumor organoids (PDTOs) for neuroendocrine cancers, identifies therapeutic vulnerabilities, and highlights EGF dependency in pulmonary neuroendocrine tumors.

bioRxiv · Oct 31, 2022Cancer Biology