Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1
E. Kurz, S. Chen, E. Vucic, G. Baptiste, C. Loomis, P. Agarwal, C. Hadju, D. Bar-Sagi, L. K. Mahal
The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.
bioRxiv · Mar 10, 2021Cancer Biology