L. K. Mahal

Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses

The paper analyzes baseline multi-omic data from influenza vaccine recipients to identify pre-immune states predictive of vaccination responses.

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators

The paper uses CRISPR screens and lectin microarrays to identify TM9SF3 and the CCC complex as novel regulators of high mannose N-glycan synthesis.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

miRNA upregulate protein and glycan expression via direct activation in proliferating cells

The paper shows miRNA can directly upregulate protein and glycan expression in proliferating cells, challenging the dominant view of miRNA repression.

Reduced inflammatory response and promoted multiciliated cell differentiation in mice protected by defective interfering influenza virus

This study shows that defective interfering influenza virus protects mice from viral infection by reducing inflammation and promoting multiciliated cell differentiation, independent of type I and III IFN signaling.

Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands

This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.

A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities

The paper uses machine learning and manual annotation to define the glycan-binding specificities of 57 lectins based on microarray data.

High-throughput analysis of B3GLCT regulation predicts phenotype of Peters' Plus Syndrome in line with the miRNA Proxy Hypothesis

The paper develops miRFluR to analyze miR:target interactions and validates miRs targeting B3GLCT, showing high false positive rates in prediction and supporting the miRNA Proxy Hypothesis for Peters Plus Syndrome.

Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.

Sex-specific glycosylation of secreted immunomodulatory proteins in the filarial nematode Brugia malayi

This study identifies sex-specific glycosylation patterns in immunomodulatory proteins of Brugia malayi, suggesting targets for disrupting parasitic transmission.

Glycomic analysis reveals a conserved response to bacterial sepsis induced by different bacterial pathogens.

The paper identifies a conserved glycomic signature in sepsis across different bacterial pathogens by analyzing serum glycomes in mouse models.

Age-dependent glycomic response to the 2009 pandemic H1N1 influenza virus and its association with disease severity

The paper examines age-dependent glycomic responses to the 2009 H1N1 influenza virus and links these responses to disease severity in a ferret model.

Glycomic analysis of host-response reveals high mannose as a key mediator of influenza severity

This study identifies high mannose as a key mediator of influenza severity through glycomic analysis in a ferret model.

O-fucosylation of thrombospondin-like repeats is required for processing of MIC2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites