Author

E. Kurz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Approach:microscopy & imaging analysis· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

G. J. Schuetz· 3 shared J. B. Huppa· 3 shared M. Dustin· 3 shared A. Kvalvaag· 2 shared E. Sevcsik· 2 shared J. Hellmeier· 2 shared M. Brameshuber· 2 shared P. F. Cespedes· 2 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

G. J. Schuetz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse through distinct adaptors

A. Kvalvaag, P. F. Cespedes, S. Valvo, D. Saliba, E. Kurz, K. Korobchevskaya, M. Dustin

The paper shows clathrin mediates TCR internalization and vesicular release at the immunological synapse through distinct adaptors HRS/STAM2 and EPN1.

bioRxiv · Feb 2, 2022 · PreprintCell Biology

3D single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm

L. Velas, M. Brameshuber, J. B. Huppa, E. Kurz, M. Dustin, P. Zelger, A. Jesacher, G. J. Schuetz

This study uses 3D-SMLM to measure the cleft size in immunological synapses between T-cells and lipid bilayers, finding distances of 18-31 nm.

bioRxiv · Aug 9, 2021Biophysics

Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins

J. Hellmeier, R. Platzer, V. Muehlgrabner, M. C. Schneider, E. Kurz, G. J. Schuetz, J. B. Huppa, E. Sevcsik

This study evaluates strategies for site-specific decoration of DNA origami with functional proteins, finding that PNA-based conjugation best preserves protein function and stoichiometry.

bioRxiv · Jul 1, 2021Biophysics

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

P. F. Cespedes, A. K. Jainarayanan, L. Fernandez-Messina, S. Valvo, D. G. Saliba, A. Kvalvaag, L. Chen, E. Kurz, C. Ganskow, H. Colin-York, M. Fritzsche, P. Yanchun, T. Dong, E. Johnson, J. A. Siller-Farfan, , M. L. Dustin

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

bioRxiv · May 29, 2021 · PreprintImmunology

Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

E. Kurz, S. Chen, E. Vucic, G. Baptiste, C. Loomis, P. Agarwal, C. Hadju, D. Bar-Sagi, L. K. Mahal

The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.

bioRxiv · Mar 10, 2021Cancer Biology

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

S. Sivakumar, E. Abu-Shah, D. Ahern, E. H. Arbe-Barnes, N. Mangal, S. Reddy, A. Rendek, A. Easton, E. Kurz, M. Silva, L. R. Heij, Z. Soonawalla, R. Bashford-Rogers, M. R. Middleton, M. Dustin

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

bioRxiv · Jun 20, 2020 · PreprintImmunology